Review the evidence signals before interviewing. Then use the anchored descriptions—not instinct alone—to choose the score that best matches each answer.
01
Evaluation factor
Technical proficiency
35% weight
Check hands-on command of variant calling and annotation: BWA or Minimap2, GATK best practices, VEP or ANNOVAR, plus scripting in Python, R, and bash on Slurm or cloud batch.
Evidence to listen for
Command of the languages, frameworks, and data tools the role actually uses
Understands correctness, performance, and failure modes, not just syntax
Has opinions on testing and can justify them
Reads and reasons about code they did not write
Five-point scoring guide
1
Poor
Cannot work independently; fundamentals are missing.
2
Needs Improvement
Weak fundamentals; output needs heavy review.
3
Satisfactory
Competent for the role; needs guidance on complex or unfamiliar work.
4
Very Good
Strong practitioner; handles hard problems with little guidance.
5
Excellent
Names specific pipeline steps, filtering thresholds, and reference builds (GRCh37 versus GRCh38) used, and explains why each tool was chosen.
02
Evaluation factor
Systems and trade-offs
25% weight
Probe how they handled scale and reproducibility: WDL or Nextflow workflows, joint genotyping across thousands of samples, storage of BAM and VCF, runtime versus cost decisions.
Evidence to listen for
Reasons about scale, latency, cost, and failure before writing code
Names the trade-off they chose and what they gave up
Understands the data lifecycle end to end
Anticipates what breaks at ten times the volume
Five-point scoring guide
1
Poor
No thinking beyond the immediate task; no awareness of scale or failure.
2
Needs Improvement
Limited architectural awareness; struggles with design decisions.
3
Satisfactory
Works within an existing design; makes sound local decisions.
4
Very Good
Designs for scale and maintainability; articulates trade-offs clearly.
5
Excellent
Discusses concrete trade-offs such as gVCF versus single-sample calling, coverage depth targets, and where they accepted sensitivity loss for turnaround.
03
Evaluation factor
Evidence and rigour
25% weight
Assess statistical rigour: population structure correction in GWAS, multiple testing control, coverage and contamination QC metrics, ACMG criteria or ClinVar evidence weighting for variant classification.
Evidence to listen for
Validates results rather than trusting output
Knows how their work is measured and what a bad result looks like
Can describe a time their own analysis or model was wrong and how they caught it
Careful about data quality, leakage, and silent failure
Five-point scoring guide
1
Poor
Ships unvalidated work; no notion of how correctness is checked.
2
Needs Improvement
Validates superficially; misses obvious quality or leakage issues.
3
Satisfactory
Reasonable checks in place; rigour drops under time pressure.
4
Very Good
Validates thoroughly; can name a real error they caught in their own work.
5
Excellent
Cites QC metrics they gated on (Ti/Tv, call rate, het/hom ratio) and shows scepticism toward findings lacking orthogonal confirmation.
04
Evaluation factor
Collaboration and communication
15% weight
Look for work with wet lab staff, clinical geneticists, or PIs: handling ambiguous requests, reporting incidental findings, and documenting analyses so results survive audit or reanalysis.
Evidence to listen for
Explains technical work to non-technical stakeholders
Gives and takes code or peer review constructively
Documents enough that the work survives their absence
Aligns with team process rather than working around it
Five-point scoring guide
1
Poor
Cannot work in a team; resistant to feedback.
2
Needs Improvement
Communication issues create rework; lone-wolf tendencies.
3
Satisfactory
Adequate team member; documentation and review participation are light.
4
Very Good
Communicates well; reliable reviewer and collaborator.
5
Excellent
Describes translating variant results for clinicians or reviewers, and maintains versioned notebooks or reports others reran without help.
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