Method and rigour
Check command of variant interpretation workflows: MTHFR C677T, FADS1, APOE, CYP1A2 panels, ACMG classification limits, GWAS effect sizes, and why single-SNP claims collapse under scrutiny.
Evidence to listen for
- Follows and can justify an established methodology
- Understands contamination, bias, and chain of custody as they apply to the field
- Knows the limits of their techniques and says so
- Documents procedure so results are reproducible and defensible
Five-point scoring guide
Careless method; unaware of contamination, bias, or procedural integrity.
Knows procedures but applies them inconsistently; gaps in documentation.
Sound standard practice; less certain outside familiar techniques.
Rigorous and well documented; understands the limits of each method.
Cites specific variants with allele frequencies and effect sizes, distinguishes validated gene-diet interactions from underpowered or unreplicated association findings.